CHEMISTRY: ENVIRONMENTAL CHEMISTRY
Overview
- Environmental chemistry is the study of chemical and biochemical phenomena that occur in natural places
- Environmental chemistry is used to detect and identify the nature and source of pollutants, including
- Heavy metal contamination of land by industry. These can transported to water bodies and taken up ingested by living organisms
- Nutrients leaching from agricultural land into water sources
- Urban pollutants runoff. Typical pollutants include petrol and other fuel, metals, nutrients and sediments
- Common environmental phenomena arising out of contamination include acid rain, soil salination and ocean acidification
WATER QUALITY PARAMETERS
- Dissolved Oxygen (Oxygen Saturation)
- It is a relative measure of the amount of oxygen dissolved in water.
- Supersaturation (excess of oxygen) can be harmful to organisms and also cause decompression sickness
- It is expressed in mg/l
- It is a relative measure of the amount of oxygen dissolved in water.
- Chemical Oxygen Demand (COD)
- COD is used to indirectly measure the amount of organic compounds in water
- It is expressed in mg/l, which indicates the amount of oxygen consumed per litre of water
- COD is used to indirectly measure the amount of organic compounds in water
- Biochemical Oxygen Demand (BOD)
- BOD measures the rate of uptake of oxygen by microorganisms in water
- BOD is measured at a temperature of 20 C and over a period of 5 days in the dark
- BOD is widely used to determine the threshold at which treated wastewater can be re-introduced into the environment
- Pristine rivers have a BOD of below 1 mg/l. Municipal sewage treated effectively by a three-stage process would have BOD of 20 mg/l or less
- BOD measures the rate of uptake of oxygen by microorganisms in water
- Total Dissolved Solids (TDS)
- TDS is a measure of combined content of all inorganic and organic substances contained in a liquid
- TDS is generally not considered a primary pollutant, but is used to indicate the aesthetic characteristics of drinking water
- High TDS levels generally indicate hard water
- Drinking water is expected to have a TDS of 100 mg/l or less
- TDS is different from TSS (Total Suspended Solids). The former are those solids that are small enough to pass through a filter of size 2 um, while the latter are those solids that cannot pass through
- TDS is a measure of combined content of all inorganic and organic substances contained in a liquid
ENVIRONMENTAL POLLUTION PHENOMENA
Acid rain
- Acid rain is form of rain that is unusually acidic i.e. has low pH
- Acid rain is mostly caused by emission of sulphur, nitrogen and carbon which react with water molecules in the atmosphere to produce acids
- The biggest human activity causes of acid rain include coal-based power plants, factories and automobile emissions
- It can also be caused by natural phenomena such as
- lightning strikes (which splits nitrogen compounds)
- volcanic eruptions (which release large quantities of sulphur dioxide)
- Natural (unpolluted) rain is slightly acidic with pH of 5.2 due to the reaction of carbon dioxide with water to produce carbonic acid
- Acid rain has many adverse effects including
- Damage to aquatic animals
- Damage to soil chemistry by killing off essential microbes
- Loss of forests and vegetation
- Human illnesses such as cancer, asthma and other diseases
- Damage to buildings and historical monuments (esp. those made of limestone and marble)
Ocean acidification
- Ocean acidification is the continuing phenomenon of decreasing pH in the world’s oceans
- Between 1751 and 1994, ocean pH is estimated to have decreased from 8.179 to 8.104 (decrease of 0.075). Ocean pH is expected to decrease by a further 0.3-0.5 by 2100
- This acidification is mainly the result of uptake of carbon dioxide from the atmosphere. The world’s oceans naturally absorb carbon dioxide from the atmosphere, indirectly mitigating climate change
- Ocean acidification adversely affects marine organisms especially calcifying organisms like corals, crustaceans and molluscs, and also affects other organisms by entering the food chain
Soli salination
- Salt affected soils are caused by excess accumulation of salts at the soil surface
- Salt can be transported to the soil surface by capillary action from salt-laden water tables, or by human activity
- Increasing soil salinity adversely affects soil quality and vegetation
- Human activities that increase soil salinity include
- Land clearing
- Aquaculture activities (shrimp farms etc)
- Irrigation (over a period time causes deposition of salts)
- The adverse effects of salination include
- loss of soil fertility
- damage to infrastructure (such as roads etc)
- damage to plant growth and yield
- deterioration of underground water quality
- soil erosion
COMMON ENVIRONMENTAL TOXINS
- Chlorofluorocarbons
- They are organic compounds that contain carbon, chlorine and fluorine
- Examples of CFCs include Freon, Teflon
- CFCs have been widely used as refrigerants, propellants (in aerosols) and solvents
- The use of CFCs has been banned under the Montreal Protocol due to their adverse effect on the ozone layer
- Endocrine disruptors
- Endocrine disruptors are substances that affect the function of natural hormones in the body
- Food is the main source of exposure to endocrine disruptors
- There are five main types of endocrine disruptors:
- DDT
- Polychlorinated biphenyls
- Bisphenol A
- Polybrominated diphenyl ethers
- Pthalates
- DDT
- Dichlorodiphenyltrichloroethane (DDT) is one of the most well-known synthetic pesticides
- DDT is one of the most effective and simple to deploy pesticides, especially to fight mosquitoes that cause malaria and typhus
- DDT has significant adverse effect on aquatic life, insects and humans (esp. diabetes and reproductive disorders)
- It is a significant reproductive toxicant for certain bird species, and is a major reason for the decline of the bald eagle, brown pelican peregrine falcon and osprey. This is the main reason DDT use has been banned
- The use of DDT for agricultural use has been banned under the Stockholm Convention, however it can still be used for disease vector control (mosquito eradication)
- Polychlorinated biphenyls (PCBs)
- PCBs are a class of industrial compounds
- They are used mainly as industrial coolants and lubricants
- Exposure to PCBs increases the risk of skin cancer, brain cancer and liver cancer. Additionally it also increases childhood obesity and the risk of developing diabetes
- The use of PCBs was banned in 1977
- Bisphenol A (BPA)
- BPA is an organic compound with two functional phenol groups
- BPA is used as a building block of several important plastics and plastic additives
- It is found commonly in water bottles, plastic food containers and the lining of infant formula cans
- The use of BPA has been linked to diabetes, mammary and prostrate cancers, reproductive problems, obesity and neurological disorders
- BPA use has not been banned
- Polybrominated diphenyl ethers (PBDE)
- PBDEs are a class of compounds used as flame retardants
- They are used commonly in televisions, computers, electronics, carpets, bedding, clothing car components etc
- PBDEs have the potential to affect thyroid balance, and contribute to a variety of neurological and developmental disordersincluding learning disabilities and low intelligence
- Many of the most common PBDEs were banned by the European Union in 2006
- Phthalates
- Phthalates are esters of phthalic acid
- They are mainly used as plasticisers to soften polyvinyl chloride (PVC)
- Phthalates are found in soft toys, flooring, medical equipment, cosmetics and air fresheners
- Phthalates have been shown to have adverse effects on the male reproductive system
- The EU and the US have begun phasing out widespread use of phthalates
- Dioxins
- Polychlorinated dibenzodioxins (PCDDs) are a group of polyhalogenatated compounds
- The main sources of Dioxins include
- By-products in the manufacture of organochlorides
- in the incineration of chlorine containing substances (like PVC)
- bleaching of paper
- natural sources like volcanoes and forest fires
- Dioxins accumulate and build up in the food chain (bioaccumulation)
- Health effects of dioxins include
- Severe form of acne called chloracne
- Abnormalities in teeth enamel of children
- Nervous system pathology
- Thyroid disorders
- Diabetes
- Damage to immune system
- Exposure to dioxins has been shown to affect the ratio of male to female births, such that more females are born than males
BIOLOGY: VACCINES
Overview
- A vaccine is a biological preparation that improves immunity to a particular disease
- Vaccines were first used by Edward Jenner (England) in the 1770s to inoculate against small pox using the cow pox microbe
- Vaccines have resulted in the eradication of small pox, one of the most contagious and deadly diseases known to man
- Other diseases like polio, measles, mumps, typhoid etc are have been significantly reduced. Currently, polio is prevalent in only four countries: Afghanistan, Pakistan, Nigeria and IndiaMechanism of action
- A vaccine is usually made from a weakened or dead form of the microbe that it is intended to fight
- It stimulates the body’s immune system to recognise the microbe as foreign, and destroy it and remember it
- When the same microbe re-appears later, the immune system easily recognises and destroys it
- When the body recognises the virulent microbe attack, it
- Neutralises the target microbe before it can enter body cells
- Destroys infected cells before the microbe can spread to other cells and multiply
Types of vaccines
- Killed vaccines: these are vaccines that contain micro-organisms that have been killed using chemicals or heat. Eg: influenza, cholera, bubonic plague, polio, hepatitis A
- Attenuated vaccines: these contain live attenuated (numerous) micro-organisms. These are usually live viruses that have been cultivated under conditions which disable their virulent properties, or use closely-related by less dangerous micro-organisms.These vaccines provide more durable immune response and are preferred type for healthy adults. Eg: yellow fever, measles, rubella, mumps, typhoid
- Toxoid vaccines: inactivated toxic compounds that cause illness. Eg: tetanus, diphtheria
- Subunit vaccines: these use protein subunits instead of the entire micro-organism as a vaccine. Eg: Hepatitis B vaccine (which uses only surface proteins), Human Papilloma Virus (HPV) vaccine (which uses subunits of influenza virus)
Effectiveness of vaccines
- Vaccines do not guarantee complete protection from a disease
- This could be due to
- Host’s immune system may not respond adequately
- Host may have lowered immunity (such as due to diabetes, HIV, steroid use etc)
- Host may not have a B cell capable of producing antibodies to that particular antigen
- The efficacy of a vaccine depends on a number of factors
- The disease itself
- The strain of vaccine
- Following the schedule of vaccinations
- Individual host factors
- Genetic and ethnic predisposition
- Most vaccines use adjuvants to boost immune system response. Adjuvants are compounds added to the vaccine that increase the immune response, without having any specific antigenic effect by themselves.
- Aluminum salts like aluminium phosphate and aluminium hydroxide are the most common adjuvants used
List of important vaccines
Vaccine | Disease | Type | Notes |
Anthrax vaccine | Anthrax | Protein subunit | |
Bacillus Calmette-Guerin (BCG) | Tuberculosis | Live bacteria | |
DTP | Diphtheria
Pertussis (whoopoing cough)
Tetanus
| ||
Gardasil
(Human Papilloma Virus (HPV))
| Cervical cancer | Protein subunit | |
Polio vaccine | Polio | Killed/inactivated | Polio is prevalent only in humans
Currently polio has been eradicated from all countries except Afghanistan, Pakistan, Nigeria and India
|
MMR | Measles
Mumps
Rubella
| ||
Meningococcal vaccine | Meningococcus | ||
Rabies vaccine | Rabies | Attenuated | |
Yellow fever vaccine | Yellow fever | Attenuated |
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